Table 2. DAVID analysis of genes that correlate with high Vav3 expression.
| Category | Count | P |
|---|---|---|
| Annotation cluster 1 | Enrichment score: 4.33 | |
| Focal adhesiona (KEGG_PATHWAY) | 18 | 5.1E−6 |
| Regulation of actin cytoskeletona (KEGG_PATHWAY) | 18 | 8.0E−6 |
| Proteoglycans in cancer (KEGG_PATHWAY) | 13 | 2.5E−3 |
| Annotation cluster 2 | Enrichment score: 3.42 | |
| Cadherin binding involved in cell–cell adhesiona (GOTERM_MF) | 18 | 8.1E−5 |
| Cell–cell adherens junctiona (GOTERM_CC) | 19 | 1.1E−4 |
| Cell–cell adhesiona (GOTERM_BP) | 11 | 6.3E−3 |
| Annotation cluster 3 | Enrichment score: 2.58 | |
| Outflow tract morphogenesis (GOTERM_BP) | 9 | 1.5E−5 |
| Palate development (GOTERM_BP) | 6 | 3.2E−2 |
| Heart looping (GOTERM_BP) | 5 | 4.0E−2 |
| Annotation cluster 4 | Enrichment score: 2.05 | |
| Differentiation (UP_KEYWORDS) | 24 | 2.1E−3 |
| Neurogenesis (UP_KEYWORDS) | 12 | 6.4E−3 |
| Nervous system development (GOTERM_BP) | 14 | 5.2E−2 |
| Annotation cluster 5 | Enrichment score: 1.90 | |
| GTP-bindinga (UP_KEYWORDS) | 15 | 3.6E−3 |
| GTPase activitya (GOTERM_MF) | 12 | 4.4E−3 |
| Small GTPase mediated signal transductiona (GOTERM_BP) | 12 | 1.1E−2 |
| Nucleotide phosphate-binding region:GTPa (UP_SEQ_FEATURE) | 15 | 1.2E−2 |
| GTP bindinga (GOTERM_MF) | 16 | 1.5E−2 |
| Small GTP-binding protein domaina (INTERPRO) | 9 | 1.5E−2 |
| P-loop containing nucleoside triphosphate hydrolasea (INTERPRO) | 24 | 1.1E−1 |
| Annotation cluster 6 | Enrichment score: 1.81 | |
| Actin-bindinga (UP_KEYWORDS) | 13 | 2.6E−3 |
| Actin filament bindinga (GOTERM_MF) | 8 | 2.1E−2 |
| Brush border (GOTERM_CC) | 6 | 2.2E−2 |
| Actin bindinga (GOTERM_MF) | 13 | 5.1E−2 |
| Annotation cluster 7 | Enrichment score: 1.76 | |
| Tight junctiona (KEGG_PATHWAY) | 9 | 1.4E−3 |
| Bicellular tight junctiona (GOTERM_CC) | 6 | 1.9E−2 |
| Tight junctiona (UP_KEYWORDS) | 5 | 2.0E−1 |
Annotation cluster defines a group of terms having similar biological functions. The enrichment score is the rank of the annotation cluster based on its significance within the dataset tested. The count column refers to number of genes involved in the same category.
a
Annotation cluster categories related to barrier function.