Table 2.
Genotype frequency distribution of ADAM33 T1, T2, ST+4 and S1 polymorphisms and its association with asthma.
| SNP | Best Genetic Model | Genotype frequency, number (%) | OR (95% CI) | P | AIC (BIC) | ||
|---|---|---|---|---|---|---|---|
| Genotype | Healthy | Asthmatic | |||||
|
| |||||||
| T1 | Dominant | A/A | 53 (61.6) | 38 (39.6) | 1.00 | .001 | 241 (251) |
| rs2280091 | A/G-G/G | 33 (38.4) | 58 (60.4) | 2.70 (1.46–5.01)a | |||
| T2 | Dominant | G/G | 52 (61.9) | 41 (43.6) | 1.00 | .008 | 238 (247) |
| rs2280090 | G/A-A/A | 32 (38.1) | 53 (56.4) | 2.28 (1.22–4.23)a | |||
| ST+4 | NA | A/A | 32 (53.3) | 48 (48.5) | 1.00 | 0.49 | 211 (221) |
| rs44707 | A/C-C/C | 28 (46.7) | 51 (51.5) | 1.26 (0.66–2.43) | |||
| S1 | NA | C/C | 80 (97.6) | 90 (93.8) | 1.00 | 0.28 | 244 (254) |
| rs3918396 | C/T | 2 (2.4) | 6 (6.2) | 2.38 (0.46–12.37) | |||
Analysis of allele frequencies adjusted by covariate gender, showing odds ratio (OR) and 95% confidence interval (CI) for the best fit model of SNP association with asthma. For each SNP, 4 models were tested, using the most frequent homozygous genotype as reference. The OR and CI for only the best fit genetic model are shown, selected by their lowest index criteria values (AIC and BIC). NA means None Available.