Table 1.
Severe clinical events reported as first clinical event in p.N215S and classic Fabry disease patients from the clinical centers participating in the study
| Severe clinical events | p.N215S males (n = 59) | Classic males (n = 164) | p.N215S females (n = 66) | Classic females (n = 237) | ||||
|---|---|---|---|---|---|---|---|---|
| n (%) | Mean age (SD), years | n (%) | Mean age (SD), years | n (%) | Mean age (SD), years | n (%) | Mean age (SD), years | |
| Any event | 19 (32) | 52.4 (11.8) | 54 (33) | 38.3 (10.9) | 6 (9) | 50.2 (11.6) | 47 (20) | 49.2 (13.6) |
| Cardiac event | 18 (31) | 52.3 (12.1) | 34 (21) | 43.3 (10.6) | 5 (8) | 51.1 (12.8) | 36 (15) | 50.2 (13.6) |
| Angina pectoris | ‐ | ‐ | 9 (5) | ‐ | 3 (5) | ‐ | 14 (6) | ‐ |
| Arrhythmia | 10 (17) | ‐ | 13 (8) | ‐ | 1 (2) | ‐ | 14 (6) | ‐ |
| Congestive heart failure | 1 (2) | ‐ | 4 (2) | ‐ | ‐ | ‐ | ‐ | ‐ |
| Myocardial infarction | 1 (2) | ‐ | 2 (1) | ‐ | ‐ | ‐ | ‐ | ‐ |
| Significant cardiac procedure | 6 (10) | ‐ | 6 (4) | ‐ | 1 (2) | ‐ | 8 (3) | ‐ |
| Renal event | ‐ | ‐ | 25 (15) | 36.9 (11.3) | 1 (2) | 45.0 | 1 (<1) | 41.0 |
| Chronic dialysis | ‐ | ‐ | 23 (14) | ‐ | ‐ | ‐ | ‐ | ‐ |
| Transplant | ‐ | ‐ | 2 (1) | ‐ | 1 (2) | ‐ | 1 (<1) | ‐ |
| Cerebrovascular event | 1 (2) | 54.1 | 12 (7) | 34.8 (8.8) | ‐ | ‐ | 15 (6) | 47.2 (13.7) |
| Hemorrhagic stroke | ‐ | ‐ | 2 (1) | ‐ | ‐ | ‐ | ‐ | ‐ |
| Ischemic stroke | 1 (2) | ‐ | 10 (6) | ‐ | ‐ | ‐ | 15 (6) | ‐ |
| Death | ‐ | ‐ | 2 (1) | 47.0 (7.7) | ‐ | ‐ | 1 (<1) | 66 |
SD, standard deviation.