Table 1.

Age-defined cohort baseline characteristics

	Age ≥ 55 (n=126)	Age < 55 (n=47)	p-value
Male, n (%)	72 (57.1)	29 (61.7)	0.61
Age in years, mean ± SD	68.2 ± 7.8	41.3 ± 9.2	NA
Race, n (%)			0.35
Caucasian (White)	115 (91.3)	43 (91.5)
African American	9 (7.1)	2 (4.3)
Asian	1 (0.8)	1 (2.1)
Pacific Islander	0 (0)	1 (2.1)
Other	1 (0.0)	0 (0)
BMI, median (25th, 75th)	28.8 (24.2, 34.9)	27.5 (24.1, 37.2)	0.78
Number of comorbidities, n (%)			0.0003
0	22 (17.5)	20 (42.6)
1	32 (25.4)	15 (31.9)
2	30 (23.8)	8 (17.0)
≥3	42 (33.3)	4 (8.5)
Charlson comorbidity index, median (25th, 75th)	5 (4, 7)	1 (0, 2)	0.0001
APACHE II, median (25th, 75th)	23 (17, 27)	18 (13, 23)	0.0023
Inter-facility hospital transfer, n (%)	62 (49.2)	20 (42.6)	0.50
Hospital Admission Diagnosis, n (%)			0.31
Intra-abdominal sepsis	26 (20.6)	9 (19.1)
NSTI	17 (13.5)	13 (27.7)
Acute vascular disease - aortic/mesenteric	16 (12.7)	1 (2.1)
Planned surgical procedure	14 (11.1)	7 (14.9)
Trauma	9 (7.1)	7 (14.9)
Surgical Site Infection	8 (6.3)	2 (4.3)
Necrotizing pancreatitis	7 (5.6)	2 (4.3)
Pneumonia	4 (3.2)	1 (2.1)
UTI	4 (3.2)	2 (4.3)
Acute vascular disease - extremity	2 (1.6)	0 (0)
Other - non-infectious	13 (10.3)	2 (4.3)
Other - acute infection	6 (4.8)	1 (2.1)
Delayed sepsis (onset >2 days after admission), n (%)	45 (35.7)	15 (31.9)	0.72
Sepsis severity, n (%)			0.0598
Severe sepsis	62 (49.2)	31 (66.0)
Septic shock	64 (50.8)	16 (34.0)
Primary sepsis diagnosis, n (%)			0.33
Intra-abdominal sepsis	62 (49.2)	19 (40.4)
NSTI	18 (14.3)	15 (31.9)
Pneumonia	23 (18.3)	7 (14.9)
UTI	10 (7.9)	2 (4.3)
Surgical Site Infection	6 (4.8)	2 (4.3)
Empyema	3 (2.4)	0 (0)
Bacteremia/CLABSI	3 (2.4)	0 (0)
Other	1 (0.8)	1 (2.1)
Source control procedure, n (%)	81 (64.3)	31 (66.0)	0.86

SD, standard deviation; CLABSI, central line-associated bloodstream infection; NSTI, necrotizing soft tissue infection; UTI, urinary tract infection.