Table 2.
Clinical outcomes of young vs aged cohort
| Age ≥ 55 (n=126) | Age < 55 (n=47) | p-value | q-value1 | |
|---|---|---|---|---|
| Hospital mortality, n (%) | 20 (15.9) | 1 (2.1) | 0.016* | 0.0373* |
| ICU LOS, median (25th, 75th) | 13 (6, 21) | 11 (5, 26) | 0.70 | 0.73 |
| Hospital LOS, median (25th, 75th) | 18 (11, 34) | 21 (8, 36) | 0.61 | 0.71 |
| Maximum SOFA score, median (25th, 75th) | 9 (7, 12) | 7 (5, 9) | 0.0009* | 0.0042* |
| MOF incidence2, n (%) | 81 (64.3) | 19 (40.4) | 0.0057* | 0.02* |
| Organ system dysfunction2, n (%) | ||||
| Pulmonary | 71 (56.4) | 21 (44.7) | 0.23 | 0.36 |
| CNS | 72 (57.1) | 23 (48.9) | 0.39 | 0.50 |
| Cardiovascular | 63 (50.0) | 13 (27.7) | 0.01* | 0.028* |
| Hepatic | 8 (6.4) | 2 (4.3) | 0.73 | 0.73 |
| Coagulation | 10 (7.9) | 1 (2.1) | 0.29 | 0.41 |
| Renal | 32 (25.4) | 6 (12.8) | 0.10 | 0.18 |
| Clinical trajectory, n (%) | 0.062 | 0.12 | ||
| CCI/Early death | 74 (58.7) | 20 (42.6) | ||
| Rapid recovery | 52 (41.3) | 27 (57.5) | ||
| Discharge disposition, n (%) | 0.0001* | 0.0007* | ||
| “Good” disposition | 42 (33.3) | 31 (66.0) | 0.0001* | 0.0007* |
| Home | 13 (10.3) | 13 (27.7) | ||
| Home with healthcare services | 19 (15.1) | 16 (34.0) | ||
| Rehab | 10 (7.9) | 2 (4.3) | ||
| “Poor” disposition | 84 (66.7) | 16 (34.0) | 0.0001* | 0.0007* |
| LTAC | 25 (19.8) | 6 (12.8) | ||
| SNF | 25 (19.8) | 4 (8.5) | ||
| Another Hospital | 8 (6.4) | 5 (10.6) | ||
| Hospice | 6 (4.8) | 0 (0) | ||
| Death | 20 (15.9) | 1 (2.1) | ||
1
Benjamini & Hochberg correction for multiple comparisons,
*
represents statistical significance at false discovery rate <5%.
2
Incidence of organ system failure onset during hospitalization as defined by modified SOFA criteria, see Methods and SDC1.
SOFA, sequential organ failure assessment score; MOF, multiple organ failure by SOFA criteria; CCI, chronic critical illness (>14 day ICU LOS with ongoing organ dysfunction); Rehab, inpatient rehabilitation facility; LTAC, long-term acute care facility; SNF, skilled nursing facility.