TABLE 3.
Comparison of the Mean Values Based on ANOVA Test (Second Column), for Differentiation of Normal Tissue (NT) vs. Infiltrative Edema (IE) vs. Active Tumor (AT) Simultaneously, and Evaluating the Diagnostic Performances of Individual Parameters in Differentiating Pairwise Regions, ie, “NT” from “IE,” “NT” from “AT,” and “IE” from “AT” Using Cross-validated LDA Methoda
| Feature | ANOVA Test (P-values) |
NT from IE | NT from AT | IE from AT | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P-values | Sens. | Spec. | Acc. | AUC (95% CI) | P-values | Sens. | Spec. | Acc. | AUC (95% CI) | P-values | Sens. | Spec. | Acc. | AUC (95% CI) | ||
| T1_SUB | 0.203 | 0.563 | 100 | 0 | 71.4 | 68.8 (45.0–92.5) | 0.176 | 50 | 100 | 78.6 | 81.2 (54.1–100) | 0.462 | 1.9 | 95.1 | 73.7 | 67.5 (36.4–98.1) |
| T2_ISO | 0.001 | 0.018 | 87.0 | 75.9 | 83.9 | 89.4 (77.0–100) | 0.000 | 77.9 | 87.5 | 83.5 | 95.8 (86.0–100) | 0.913 | 0.0 | 100 | 76.9 | 59.1 (35.5–82.8) |
| FLAIR | 0.001 | 0.016 | 89.8 | 64.7 | 82.7 | 90.6 (79.0–100) | 0.000 | 67.9 | 87.5 | 79.1 | 93.7 (81.2–100) | 0.958 | 0.0 | 100 | 76.9 | 49.2 (21.8–76.5) |
| ADC | 0.005 | 0.002 | 89.6 | 87.5 | 89.0 | 90.0 (76.9–100) | 0.001 | 100 | 87.5 | 92.9 | 100 (100–100) | 0.473 | 0.64 | 100 | 77.1 | 65.0 (41.9–88.1) |
| CBV | 0.004 | 0.963 | 100 | 0 | 71.4 | 50.7 (24.1–77.3) | 0.003 | 66.7 | 87.5 | 78.6 | 75.0 (41.1–100) | 0.018 | 51.3 | 95.4 | 85.2 | 80.0 (50.7–100) |
| MD | 0.000 | 0.001 | 93.9 | 63.8 | 85.3 | 93.8 (85.0–100) | 0.001 | 100 | 100 | 100 | 100 (100–100) | 0.601 | 1.3 | 100 | 77.2 | 68.3 (46.3–90.3) |
| FA | 0.010 | 0.082 | 94.6 | 12.9 | 71.3 | 70.6 (50.2–91.0) | 0.007 | 100 | 85.5 | 91.8 | 100 (100–100) | 0.209 | 0.0 | 100 | 76.9 | 86.7 (71.0–100) |
| Q | 0.116 | 0.215 | 100 | 0 | 71.4 | 51.9 (27.5–76.4) | 0.104 | 77.6 | 80.4 | 79.7 | 83.3 (58.6–100) | 0.990 | 5.8 | 98.6 | 77.2 | 82.5 (65.4–99.3) |
| P | 0.000 | 0.001 | 89.7 | 69.2 | 84.0 | 91.9 (81.0–100) | 0.002 | 100 | 99.1 | 99.5 | 100 (100–100) | 0.737 | 0.0 | 100 | 76.9 | 60.0 (35.3–84.7) |
| D | 0.000 | 0.002 | 90.0 | 71.4 | 84.9 | 90.6 (78.6–100) | 0.000 | 100 | 94.0 | 96.7 | 100 (100–100) | 0.251 | 9.9 | 99.0 | 78.5 | 68.3 (46.0–90.6) |
| D* | 0.748 | 0.918 | 98.9 | 0.9 | 70.9 | 60.6 (31.8–89.5) | 0.734 | 41.2 | 74.1 | 61.5 | 60.4 (24.4–95.9) | 0.855 | 0.0 | 100 | 76.9 | 52.2 (23.5–80.8) |
| f | 0.505 | 0.941 | 100 | 0 | 71.4 | 52.0 (27.1–76.8) | 0.504 | 32.6 | 86.1 | 63.7 | 59.5 (27.8–90.7) | 0.574 | 0.6 | 97.6 | 75.2 | 64.2 (39.9–88.4) |
| K | 0.1136 | 0.906 | 93.5 | 14.9 | 71.2 | 73.7 (52.9–94.6) | 0.165 | 83.3 | 86.5 | 85.2 | 87.5 (65.8–100) | 0.145 | 0 | 100 | 76.9 | 55.8 (32.4–79.3) |
| T2 | 0.018 | 0.024 | 93.3 | 66.8 | 86.0 | 84.4 (65.4–100) | 0.041 | 83.3 | 87.5 | 85.7 | 87.5 (67.8–100) | 0.890 | 0.0 | 100 | 76.9 | 50.1 (24.4–75.8) |
| PD | 0.282 | 0.461 | 100 | 0.51 | 71.6 | 66.9 (43.0–90.7) | 0.272 | 42.9 | 86.5 | 68.1 | 72.9 (42.7–100) | 0.738 | 2.1 | 100 | 77.4 | 55.1 (23.4–86.9) |
| Count | 8.9E-06 | 0.221 | 92.5 | 25.9 | 73.5 | 83.8 (68.5–98.9) | 1.0E-05 | 66.7 | 100 | 85.7 | 100 (100–100) | 6.1E-05 | 66.7 | 99.8 | 92.1 | 91.7 (79.2–100) |
The values with bold-face type under the P-values columns belong to parameters with significant P-values: the column labeled as “ANOVA Test” shows P-values obtained based on the ANOVA test for simultaneous differentiation of the three regions from each other; the other three columns under the parts “NT from IE,” “NT from AT,” and “IE from AT” parts, labeled as “P-values,” indicate P-values calculated for pairwise differentiation of the regions based on Tukey-HSD or Games-Howell tests (whichever was appropriate for each parameter). The bold-face type values under other columns indicate high accuracy