TABLE I.

Main outcomes of OS GT

Outcomes	Untreated OS mice	OS mice after GT
B-cell counts	Absent or very low	Improved but lower than BMT WT mice
B-cell phenotype	Blocked at early stage of differentiation	Normal maturation
T-cell counts	Strongly reduced	Improved but lower than BMT WT mice
T-cell phenotype	Highly activated and exhausted with oligoclonal skewed repertoire	Presence of naive cells, able to respond to stimuli and with skewed to polyclonal phenotype
IgM and IgG levels	Very low	Normal
IgE levels	Normal to high	Normal
Thymus	Absence of medulla; very low thymocyte counts	Low to normal medullary area, in correlation with VCN; improved thymocyte counts
Vaccination response	Unable to respond to vaccination	Able to mount proper antigen response
Autoantibodies	Low to high	Low or absent
Skin infiltration	Moderate to severe	Absent to moderate