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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Clin Cancer Res. 2018 Feb 7;24(17):4175–4186. doi: 10.1158/1078-0432.CCR-17-1846

Figure 2. Expression of multiple checkpoint molecules among TIL in CT2A and SMA-560 murine glioma models.

Figure 2

Tumors and blood were harvested when mice were moribund at day 21 post intracranial tumor implantation (n=5) for CT2A (A) or SMA-560 (B) tumor models. Representative histograms of checkpoint molecule expression on CD8+ T cells are shown where red represents TIL, blue represents tumor-bearing blood, and black represents relevant isotype control. For graphs, red represents TIL, blue represents tumor-bearing blood, and black represents naïve blood. Significance was determined using unpaired t-test between control and tumor-bearing samples. *p<0.05; ***p<.001.