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. 2018 Jul 19;103(2):171–187. doi: 10.1016/j.ajhg.2018.06.009

Figure 3.

Figure 3

Distribution of the Boundary PTCs in All Ensemble Multi-exon Transcripts

Above demarcates an individual transcript (horizontal rectangular structure) with exon junction and boundary PTC (lollipop with red filled diamond) shown as in Figure 1. Horizontal lines with double arrowheads demarcate NMD+ (pink) and NMD− (purple) regions. Each transcript is partitioned into two separate regions, i.e., NMD+ and NMD−, based on the location of the boundary PTCs.

(A) The bar plots show the relative distribution of boundary PTCs per transcript (percentile). About 51.1% and 49.2% of all Ensemble multi-exon transcripts have their boundary PTCs located within 85% of the normalized transcript length in the −1 and +1 frame, respectively. However, there are still a quarter of transcripts that have their NMD− regions encompassing more than a third of their coding sequence length.

(B) The bar plots demonstrate the distribution of boundary PTC locations with regards to the distance to the final exon of a given transcript. About 35.3% and 33.4% of all Ensemble multi-exon transcripts have their boundary PTCs located upstream of their penultimate exon in the −1 and +1 frame, respectively.