Table 8.
Leukemia characteristics | ||||||||
---|---|---|---|---|---|---|---|---|
Serial number | Age/sex | Hematological diagnosis | Therapy | Phase of therapy | Neutropenia at time of diagnosis of TB | Interval (between leukemia and TB) | Outcome of leukemia | Impact of TB on therapy |
P1 | 28/M | APML | ATO + ATRA | Induction | Yes | 5 weeks | Remission | None |
P2 | 28/F | APML | ATO + ATRA | Induction | Yes | 5 weeks | Remission | None |
P3 | 30/M | APML | ATO + ATRA | Induction | Yes | 8 weeks | Remission | None |
P4 | 55/F | APML | ATO + ATRA | Induction | Yes | 3 weeks | Remission | None |
P5 | 29/F | APML | ATO + ATRA f/b maintenance with 6Mercatopurine and Methotrexate | Maintenance | Yes | 68 weeks | Remission | None |
P6 | 23/M | APML | ATO + ATRA | Induction | Yes | Simultaneous | Remission | None |
P7 | 55/M | APML | ATO + ATRA | Induction | Yes | 5 weeks | Remission | None |
Tuberculosis characteristics | ||||||
---|---|---|---|---|---|---|
Serial number | Organs involved | Site of isolation | Evidence of TB | Outcome of TB | Side effects of ATT | Follow up after diagnosis of TB |
P1 | Lung, mediastinal lymph nodes | Mediastinal node | FNA AFB positive | Improved | None | In remission at 74 weeks |
P2 | Lungs, mediastinal nodes | Mediastinal node | FNA AFB positive | Improved | None | In remission at 64 weeks |
P3 | Lungs, mediastinal node, pleura | Mediastinal node | FNA AFB positive | Improved | Hepatitis | In remission at 113 weeks |
P4 | Lungs, pleura | Pleural fluid | Clinicoradiologic | Improved | None | In remission at 64 weeks |
P5 | Lungs, pleura, pericardium, mediastinal lymph nodes, Intestine | Pleural, lung, intestine | AFB positive | Expired | – | TB diagnosed post mortem |
P6 | Lung | BAL fluid | AFB positive | Improved | None | 54 weeks |
P7 | Lung, mediastinal lymph Node | Mediastinal Node | Gene Xpert positive | Improved | None | 62 weeks |
APML acute promyelocytic leukemia, TB tuberculosis, M male, F female, AFB acid fast bacilli, ATO arsenic tri oxide, ATRA all trans retinoic acid, ATT anti tubercular therapy, BAL broncho alveolar lavage, FNA fine needle aspiration