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. 2018 Aug 7;8:11813. doi: 10.1038/s41598-018-30216-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ST14 and SPINT1 promotors are regulated by enhancer activity in colorectal cells. Luciferase reporter plasmids containing the ST14 (a) or SPINT1 (a) promoter, with or without an enhancer, were transiently transfected into Caco-2 cells (with high CDX2 levels), RKO cells (with low CDX2 levels) and the non-intestinal HeLa cells. Data are shown as the relative luciferase activity compared to the control reporter plasmid, pGL4.10. One-way ANOVA analysis was applied with ± S.E.M (n = 4), **P < 0.01, ***P < 0.001, ****P < 0.0001, n.s = non-significant. The reporter activity was normalized to the co-transfected LacZ plasmid expression.