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. 2018 Aug 7;8:11826. doi: 10.1038/s41598-018-30385-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The pool in the synthesis of PAFs that occurs under infection it is mediated by the activation of cPLA2, which recruits and hydrolyzes phosphatidylcholines for the formation of lysoPAF. The activation of cPLA2 due to extracellular stimuli (intracellular phosphorylation and Ca2+ influx) upon PAFs synthesis is initiated by the formation of lyso-PAF. Also, the action of the PAF acetylhydrolase, activated by Ca2+, and phosphorylation of lyso-PAF leads to PAF formation. PAF, Platelet activation factor; PAFR, Platelet activation factor receptor; PLC, Phospholipase; DAG, Diacylglycerol; IP3, Inositol trisphosphate; Ca2+, Calcium ions; cPLA2, Cytosolic phospholipase A2; PC, Phosphatidylcholine; AA, Arachidonic acid; Lysp-PAF, 1-O-alkyl-sn-glycer-3-phosphocholine; LPCAT, Lysophosphatidylcholine acyltransferase; Acetyl-CoA, Acetyl coenzyme A.