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. 2018 Aug 7;8:11805. doi: 10.1038/s41598-018-29546-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MED1 alterations in breast cancer patients. (A,B) Genetic and transcriptomic alterations of MED1 in breast cancer patients. MED1 copy number variations and expression alterations were found in breast cancer patients from TCGA database (A). Copy number variations of MED1 locus are correlated to variations in MED1 mRNA expression levels (B). (C) MED1 expression is significantly associated to survival in breast cancer patients. Survival data were obtained from TCGA data portal for two datasets of BC patients analysed with microarray (top graphs) or RNA sequencing (bottom graphs). Both datasets confirmed a significant positive association between MED1 expression and Overall Survival in ER+ BC patients.