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. 2018 Aug 7;8:11847. doi: 10.1038/s41598-018-30291-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chronic stress reverses the emotional phenotype and the hippocampal transcriptional signature in Tph2 KO mice. (A) Immobility time in the FST (WT n = 20, KO n = 18, WT-S n = 21, KO-S n = 17; two-way ANOVA followed by Fisher’s post-hoc tests, effect of uCMS F_3,72 = 14.907, p = 0.0002. No genotype x uCMS interaction; KO-S vs KO F_1,31 = 12.825, p = 0.0002) and (B) TST (WT n = 10, KO n = 12; WT-S n = 15, KO-S n = 14; two-way ANOVA followed by Fisher’s post-hoc tests, effect of uCMS F_3,72 = 12.282, p = 0.001. No genotype x uCMS interaction; KO-S vs KO F_1,24 = 7,646, p = 0.0108) of WT-S and KO-S mice and their respective controls. (C) Overlapping distribution of DE genes in a Venn diagram across the three comparisons (KO-S = KO-S vs KO; WT-S = WT-S vs WT; KO = KO vs WT). (D) Heat map showing how DE genes in the KO-S/KO comparison (in yellow) are regulated in the KO/WT comparison. (E) Heat map showing how DE genes in the WT-S/WT (in yellow) are regulated in the KO-S/KO and KO/WT comparisons. n indicates biological replicates. FST, Forced Swim Test; TST, Tail Suspension Test; uCMS, unpredictable Chronic Mild Stress.