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. 2018 Aug 7;8:11847. doi: 10.1038/s41598-018-30291-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impaired hippocampal adaptive mechanism to stress in KO mice. (A,B) GSEA-calculated enrichment score between the transcriptional profile of WT-S and KO mice. (C,D) Quantification and representative images of (C) BDNF (WT n = 9, KO n = 8, WT-S n = 10, KO-S n = 9, two-way ANOVA followed by Fisher’s post-hoc tests, genotype x uCMS interaction F_3,31 = 12.066, p = 0.0015; WT vs KO F_1,15 = 23.33, p = 0.0002; WT vs WT-S F_1,17 = 6.744, p = 0.0188; KO vs KO-S F_1,15 = 5.486, p = 0.0345) and (D) TrkB (WT n = 9, KO n = 8, WT-S n = 10, KO-S n = 9, two-way ANOVA followed by Fisher’s post-hoc tests, genotype x uCMS interaction F_3,31 = 5.607, p = 0.0015; KO vs KO-S F_1,14 = 15.859, p = 0.0014) protein levels measured by Western Blotting in WT-S and KO-S mice and their respective controls. Images are cropped from different blots. Full length blots are displayed in Supplementary Fig. S7. Data are expressed as mean ± s.e.m. for behavioural data, as percentage of control ± s.e.m. for biochemical data. *p < 0.05, **p < 0.01, ***p < 0.001. n indicates biological replicates.