Table 4.
The potential biomarkers and possible metabolite pathways.
| m/z | tR | Metabolite | Class | HMDB | VIP | p value | Trend∗ | Metabolic pathways |
|---|---|---|---|---|---|---|---|---|
| 181.1559 | 1.52 | D-Galactose | Carbohydrate | 00143 | 1.5497 | <0.001 | up | Galactose metabolism |
| 567.3018 | 2.13 | UDP-glucose | 00286 | 1.3043 | 0.002 | up | ||
| 132.1018 | 1.94 | L-Leucine | amino acid | 00687 | 1.4244 | <0.001 | up | Aminoacyl-tRNA biosynthesis |
| 182.0809 | 1.85 | L-Tyrosine | 00158 | 1.1778 | 0.002 | up | ||
| 496.3386 | 4.16 | LysoPC(16:0) | Glycerophospholipid | 10382 | 1.4823 | <0.001 | up | Glycerophospholipid metabolism |
| 524.3685 | 5.15 | LysoPC(18:0) | 10384 | 1.0618 | 0.008 | up | ||
| 518.3238 | 4.79 | LysoPC(18:3) | 10387 | 1.5689 | 0.007 | up | ||
| 466.2898 | 3.83 | LysoPC(14:1) | 10380 | 1.3510 | <0.001 | up | ||
| 772.5782 | 8.97 | PC(15:0/20:2) | 07946 | 1.1258 | 0.004 | up | ||
| 810.6019 | 9.38 | PC(16:0/22:4) | 07988 | 1.0647 | 0.008 | up | ||
| 676.4853 | 8.26 | PC(14:0/14:1) | 07867 | 1.5373 | <0.001 | up | ||
| 684.4608 | 9.54 | PE(14:0/18:4) | 08832 | 1.4224 | <0.001 | up | ||
| 712.4935 | 9.99 | PE(14:0/20:4) | 08838 | 1.5114 | <0.001 | up | ||
| 699.5945 | 11.93 | DG(22:0/20:5) | glyceride | 07607 | 1.4373 | <0.001 | up | |
| 577.4806 | 11.03 | DG(15:0/18:3) | 07076 | 1.005 | 0.014 | up | ||
| 302.3058 | 8.48 | Sphinganine | Sphingolipid | 00269 | 1.4622 | <0.001 | down | Sphingolipid metabolism |
| 371.3699 | 9.81 | Cholest-5-ene | Cholestene | 00941 | 1.3602 | <0.001 | down | - - - |
Note: Data were analyzed by Student's t-tests. ∗Trend: Case group versus Normal group.