Table 1.
Demographic and clinical features among Alzheimer’s disease neuropathology positive and negative participants
| Characteristica | ADNP+ | ADNP− | p |
|---|---|---|---|
| Number of subjects | 60 | 22 | NA |
| Age at initial visit (years), mean (SD) | 79.4 (7.8) | 78.7 (8.9) | 0.74 |
| Age at MRI visit (years), mean (SD) | 80.7 (7.8) | 80.3 (10.0) | 0.85 |
| Age at death (years), mean (SD) | 83.8 (7.9) | 83.6 (9.1) | 0.92 |
| Male, n (%) | 33 (55.0%) | 12 (54.6%) | 0.97 |
| Education (years), mean (SD) | 14.1 (3.2) | 13.1 (4.7) | 0.30 |
| Non-white race, n (%) | 9 (15.0%) | 3 (13.6%) | 0.50 |
| Diagnosis at visit closest to MRI, n (%) | |||
| Normal cognition | 4 (6.7%) | 8 (36.4%) | 0.003 |
| Cognitively impaired, not MCI | 0 (0%) | 1 (4.5%) | 0.60 |
| MCI | 11 (18.3%) | 7 (31.8%) | 0.31 |
| Dementia | 45 (75.0%) | 6 (27.3%) | 0.0002 |
| Global CDR at Visit closest to MRI, mean (SD) | 1.12 (0.76) | 0.75 (0.81) | 0.008 |
| Diagnosis at final study visit, n (%) | |||
| Normal cognition | 3 (5.0%) | 8 (36.4%) | 0.0009 |
| Cognitively impaired, not MCI | 0 (0.0%) | 1 (4.5%) | 0.60 |
| MCI | 6 (10.0%) | 6 (27.3%) | 0.050 |
| Dementia | 51 (85.0%) | 7 (31.8%) | < 0.0001 |
| Global CDR at final study visit, mean (SD) | 1.62 (0.91) | 0.86 (0.90) | 0.002 |
| ≥ 1 APOE e4 allele, n (%) | 32 (56.1%) | 2 (9.1%) | 0.001 |
| Time between MRI and death (years), n (%) | 3.5 (2.4) | 3.8 (2.6) | 0.71 |
Abbreviations: SD = standard deviation; ADNP = Alzheimer’s disease neuropathology; MRI = magnetic resonance imaging; CDR = Clinical Dementia Rating; MCI = mild cognitive impairment; APOE = apolipoprotein E; NA = not applicable
a
Missing data (ADNP+, ADNP−): APOE genotype (n=3, n=0); Education (n=2, n=0)