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Bar graph depicting the extent of wild-type (pH 4.4) (A) and L55P TTR (pH 5.0) (B) fibril formation after 72 h. TTR (3.6 μM)‡ alone (white bars) or with equimolar holoRBP added (black bars) was incubated in the presence of three small molecule fibril formation inhibitors (flu, flufenamic acid; dcf, diclofenac) at three concentrations (1.8, 3.6, and 7.2 μM). Fibril formation was quantified by using Congo red binding and normalized to fibril formation of TTR alone.
