Table 2.
PCT in urinary tract infections.
| Study | Type | Population | n | Age | Aim | Gold standard | AUC | Cutoffa | Sn (%) | Sp (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liao et al (2014)45 | P | First febrile UTI | 278 (75 RS) |
⩽2 y | PCT to detect RS and VUR | US, DMSA, VCUG | — | — | — | — | — | — |
| Bressan et al (2009)44 | P | First febrile UTI | 72 (14 RS) |
7 d-3 y | PCT to detect RS | DMSA VCUG |
— | 0.5 | 85.7 | 51 | — | — |
| Prat et al (2003)43 | — | First febrile UTI | 77 (13 RS) |
1 mo-12 y | PCT to distinguish uncomplicated vs severe UTI with RS | DMSA | 0.83 | 1 | 92 | 92 | 32 | 98 |
| Smolkin et al (2002)42 | P | First febrile UTI | 64 (18 RS) |
15 d-3 y | PCT to distinguish uncomplicated vs severe UTI | DMSA | — | 0.5 | 94 | 90 | 86 | 98 |
| Gervaix et al (2001)41 | P | Febrile UTI | 54 (34 RS) |
7 d-16 y | PCT to distinguish uncomplicated vs severe UTI | DMSA | — | 0.5 | 74 | 85 | — | — |
Abbreviations: AUC, area under the curve; DMSA, 99mTc-dimercaptosuccinic acid; NPV, negative predictive value; PCT, procalcitonin; P, prospective; PPV, positive predictive value; R, retrospective; RS, renal scars; Sn, sensitivity; Sp, specificity; US, ultrasound; UTI, urinary tract infection; VCUG, voiding cystourethrography; VUR, vesicoureteral reflux.
a
Cutoff value for procalcitonin. Values expressed in ng/mL.