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. 2018 Aug 6;16(3):1559325818789836. doi: 10.1177/1559325818789836

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Differences between hormesis and adaptive response phenomena. A, Hormesis is defined as a continuous function of dose with which a stimulatory (beneficial?) effect occurs at subinhibitory doses. Hormesis is a single dose or dose-rate effect (it can be observed during a chronic exposure to radiation). B, Adaptive response (AR) is defined as an infra-additive effect observed after the succession of a priming d _AR and a challenging dose D _AR separated by a period of time Δt _AR (the d _AR + Δt _AR + D _AR scenario).