Table 2.
Validation of the population-differentiating transcripts on B-cell lines using TLDA cards
| Gene name | Fold change | p-value |
|---|---|---|
| U Mann Whitney/t-test* | ||
| Genes with higher expression in Chinese | ||
| UTS2** | 25.77 | < 0.00001 |
| CHI3L2 | 1.10 | 0.75656 |
| C1ORF115 | 1.68 | 0.15560 |
| IFITM3 | 1.62 | 0.58920 |
| PLA2G4C | 1.39 | 0.16152 |
| CDC42EP5 | 1.13 | 0.75656 |
| Genes with higher expression in European | ||
| UGT2B7 | did not amplify | |
| CYP1B1 | 1.64 | 0.23404 |
| MOXD1 | 1.64 | 0.17702 |
| UGT2B17** | 3.23 | 0.00350 |
| SLC7A7 | 2.17 | 0.00120 |
| S1PR4 | 1.47 | 0.0960 |
| TBC1D4 | 1.19 | 0.08012 |
*p-values for genes: UTS2, UGT2B17, CHI3L2 and C1orf115 which did not fulfill the requirement of normal distribution were tested using U-Mann Whitney statistics; other genes, were tested with using the t-test
**Validated on blood samples (see Validation 2 section). Significant population differences (p < 0.05) are indicated in bold