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. 2018 Aug 7;18:130. doi: 10.1186/s12890-018-0700-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Shp2 inhibition improves mPAP, RVSP and RVH, without affecting SAP in MCT-induced PAH rats. a Phps-1 inhibited MCT- induced increases of mPAP and RVSP b (n = 6 for Control or MCT group, n = 5 for MCT + Phps-1group) without affecting SAP c (n = 6 for Control or MCT group, n = 4 for MCT + Phps-1 group). d Phps-1 suppressed MCT- induced increase of RVH, as indicated by RV/LV + S (n = 6 for each group). Data was presented as means ± standard deviation (SD), ** P < 0.01 and *** P < 0.001