FIG. 5.

Blocking PDGF-BB signaling significantly attenuates pericyte migration. The percentage of pericyte migration in loud sound-stimulated animals is higher than in control animals. However, pericyte migration can be significantly attenuated by pre-treatment of the animals with imatinib, a potent PDGFRβ blocker, [n_ctrl = 6; n_lss = 6; t (10) = 66.59, ****P_{(ctrl vs lss)} < 0.0001, n_{lss + imatinib} = 6; n_{lss + saline} = 6; t (10) = 118.6, ****P_{(lss + imatinib vs lss + saline)} < 0.0001, Student’s t test] or APB5, a specific blocker of PDGFRβ [n_{lss + ctrl IgG} = 8; n_{lss + APB5} = 8; t (14) = 12.61, ****P_{(lss + ctrl IgG vs lss + APB5)} < 0.0001, Student’s t test]