Fig. 6.

Concordant gene alterations in diverse murine and human tumors. The comparison of the set of CTCF-dependent genes and those differentially expressed in mouse liver tumors or in human uterine and breast tumors revealed a large overlap. The majority of these changed in the same direction (concordant) in the Ctcf hemizygous MEFs and the tumor samples. Additionally, the set of genes unique to MEFs is indicated (not differential) and those that were either not expressed or did not have a one-to-one ortholog in the human genome (not common). The concordant gene changes across these diverse tumors are highly overlapping, as seen in the Venn diagram