Table 2.
Univariate and multivariate analyses of SPAG5 expression and overall survival
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Overall survival | ||||
| Age (< 49 vs. ≥49 years) | 0.954 (0.757–1.203) | 0.692 | ||
| Gender (female vs. male) | 1.008 (0.667–1.522) | 0.971 | ||
| HBV (positive vs. negative) | 1.094 (0.816–1.466) | 0.549 | ||
| Liver cirrhosis (yes vs. no) | 0.877 (0.612–1.256) | 0.474 | ||
| Tumor size (< 5 vs. ≥5 cm) | 1.560 (1.176–2.069) | 0.002 | 1.217 (0.877–1.689) | 0.240 |
| Tumor multiplicity (single vs. multiple) | 1.361 (1.072–1.729) | 0.011 | 0.890 (0.660–1.202) | 0.448 |
| Tumor capsule (absent vs. present) | 0.528 (0.411–0.677) | 0.000 | 0.645 (0.490–0.850) | 0.002 |
| AFP (< 20 vs. ≥20 ng/mL) | 1.526 (1.167–1.994) | 0.002 | 1.329 (1.000–1.766) | 0.050 |
| Vascular invasion (yes vs. no) | 2.081 (1.556–2.784) | 0.000 | 1.243 (0.894–1.729) | 0.196 |
| Tumor differentiation | 1.363 (1.045–1.777) | 0.022 | 1.116 (0.846–1.473) | 0.438 |
| LNM (yes vs. no) | 1.652 (1.076–2.538) | 0.022 | 1.290 (0.824–2.019) | 0.266 |
| TNM (I-II vs. III-IV) | 1.905 (1.498–2.424) | 0.000 | 1.356 (0.959–1.917) | 0.085 |
| SPAG5 expression (low vs. high) | 0.954 (0.757–1.203) | 0.000 | 1.697 (1.322–2.178) | 0.000 |
AFP a-fetoprotein, HBsAg hepatitis B surface antigen, LNM lymph node metastasis, HR hazard ratio, CI confidence interval