Table 1. Sample characteristics of 11 SpiroMeta and 12 CHARGE studies contributing to the discovery analyses and three studies contributing to the replication analyses.
| Discovery studies | |||||||
|---|---|---|---|---|---|---|---|
| SpiroMeta studies | Total
sample |
n (%) Male | Ever smokers,
n (%) |
Age, mean
(SD) |
FEV
1, litres.
mean (SD) |
FVC, litres.
mean (SD) |
FEV
1/FVC,
mean (SD) |
| 1958 British Birth Cohort (B58C) | 5270 | 2961 (56·2%) | 2866 (53·3%) | 44·00 (0·00) | 3·35 (0·79) | 4·29 (1·03) | 0·788 (0·09) |
| Generation Scotland (GS:SFHS) | 8164 | 3413 (41·8%) | 3806 (46·6%) | 51·59 (13·33) | 2·78 (0·87) | 3·91 (1·01) | 0·710 (0·12) |
| Cooperative Health Research in the
Region of Augsburg (KORA F4) |
1447 | 701 (48·5%) | 900 (62·2%) | 54·82 (9·66) | 3·24 (0·85) | 4·20 (1·04) | 0·771 (0·07) |
| CROATIA-Korcula cohort
(KORCULA) |
791 | 296 (36·8%) | 418 (52·0%) | 55·56 (13·69) | 2·72 (0·83) | 3·29 (0·95) | 0·829 (0·10) |
| Lothian Birth Cohort 1936
(LBC1936) |
974 | 501 (50·6%) | 554 (55·9%) | 69·55 (0·84) | 2·38 (0·67) | 3·04 (0·87) | 0·787 (0·10) |
| Study of Health in Pomerania
(SHIP) |
1681 | 831 (49·4%) | 955 (56·8%) | 52·25 (13·43) | 3·29 (0·88) | 3·88 (1·03) | 0·848 (0·07) |
| Northern Swedish Population
Health Study (NSPHS) |
880 | 407 (46·3%) | 122 (13·9%) | 49·13 (19·96) | 2·93 (0·90) | 3·53 (1·06) | 0·831 (0·09) |
| Prospective Investigation of the
Vasculature in Uppsala Seniors (PIVUS) |
836 | 413 (49·4%) | 426 (51·0%) | 70·20 (0·17) | 2·44 (0·68) | 3·20 (0·87) | 0·76 (0·10) |
| Swiss study on Air Pollution and
Lung Disease in adults (SAPALDIA) |
2707 | 1379 (50·9%) | 1399 (51·7%) | 40·86 (10·92) | 3·65 (0·83) | 4·62 (1·04) | 0·794 (0·07) |
| The Cardiovascular Risk in Young
Finns Study (YFS) |
434 | 198 (47·3%) | 186 (44·4%) | 38·88 (5·07) | 3·73 (0·75) | 4·68 (0·99) | 0·800 (0·06) |
| Finnish Twin Cohort (FTC) | 214 | 0 (0%) | 0 (0%) | 68·73 (3·31) | 2·18 (0·47) | 2·79 (0·58) | 0·786 (0·08) |
| Total | 23,398 | ||||||
| CHARGE studies (European
Ancestry) |
Total
sample |
n (%) Male | Ever smokers,
n (%) |
Age, mean
(SD) |
FEV
1, litres.
mean (SD) |
FVC, litres.
mean (SD) |
FEV
1/FVC,
mean (SD) |
| AGES-Reykjavik study (AGES) | 1566 | 649 (41·4%) | 900 (57·5%) | 76·1 (5·62) | 2·13 (0·70) | 2·87 (0·86) | 0·744 (0·09) |
| Atherosclerosis Risk in
Communities Study (ARIC) |
10,680 | 5015 (47·0%) | 631 (59·1%) | 54·3 (5·70) | 2·94 (0·77) | 3·98 (0·98) | 0·738 (0·07) |
| Cardiovascular Health Study (CHS) | 3967 | 1737 (43·8%) | 2089 (52·7%) | 72·8 (5·55) | 2·11 (0·66) | 3·00 (0·86) | 0·702 (0·10) |
| NHLBI Family Heart Study (FAMHS) | 1651 | 718 (43·5%) | 698 (42·3) | 53·5 (12·60) | 2·91 (0·853) | 3·89 (1·05) | 0·746 (0·08) |
| Framingham Heart Study (FHS) | 7113 | 3241 (45·5%) | 3780 (53·1) | 50·7 (14·12) | 3·10 (0·925) | 4·09 (1·12) | 0·755 (0·08) |
| Health Aging and Body
Composition Study (HABC) |
1457 | 786 (53·2%) | 831 (56·5%) | 73·7 (2·83) | 2·31 (0·66) | 3·11 (0·81) | 0·741 (0·08) |
| Health2006 Study | 2714 | 1217 (44·8%) | 1577 (58·1%) | 49·4 (13·04) | 3·13 (0·82) | 3·99 (0·99) | 0·784 (0·07) |
| Health2008 Study | 687 | 297 (43·2%) | 384 (55·9%) | 46·7 (8·22) | 3·27 (0·79) | 4·13 (0·97) | 0·791 (0·06) |
| Inter99 Study (without pack-years) | 1115 | 549 (49·2%) | 1115 (100%) | 47·2 (7·76) | 3·26 (0·71) | 4·12 (0·92) | 0·796 (0·07) |
| Inter99 Study (with pack-years) | 4179 | 2027 (48·5%) | 2307 (55·2%) | 45·8 (7·95) | 3·21 (0·76) | 4·10 (0·97) | 0·788 (0·08) |
| Multi-Ethnic Study of
Atherosclerosis (MESA) |
1323 | 654 (49·4%) | 751 (56·8%) | 66·0 (9·8) | 2·57 (0·76) | 3·51 (0·10) | 0·733 (0·08) |
| The Rotterdam Study (RS) | 546 | 299 (54·8%) | 382 (70·0%) | 79·4 (5·00) | 2·27 (0·68) | 3·03 (0·86) | 0·750 (0·08) |
| Total | 36,998 | ||||||
| CHARGE studies (African
Ancestry) |
Total
Sample |
n (%) Male | Ever smokers,
n (%) |
Age, mean
(SD) |
FEV
1, litres.
mean (SD) |
FVC, litres.
mean (SD) |
FEV
1/FVC,
mean (SD) |
| Atherosclerosis Risk in
Communities Study (ARIC) |
3180 | 1183 (37·2%) | 1680 (59·1%) | 53·6 (5·83) | 2·48 (0·65) | 3·25 (0·82) | 0·765 (0·08) |
| Cardiovascular Health Study (CHS) | 624 | 232 (37·2%) | 340 (54·4%) | 73·2 (5·49) | 1·76 (0·58) | 2·48 (0·80) | 0·717 (0·11) |
| Health Aging and Body
Composition Study (HABC) |
943 | 433 (45·9%) | 543 (57·6%) | 73·4 (2·90) | 1·96 (0·57) | 2·61 (0·71) | 0·749 (0·09) |
| Jackson Heart Study (JHS) | 2143 | 793 (36·8%) | 688 (31·9%) | 52·8 (12·6) | 2·43 (0·72) | 3·02 (0·86) | 0·807 (0·09) |
| Multi-Ethnic Study of
Atherosclerosis (MESA) |
861 | 404 (46·9%) | 467 (54·2%) | 65·6 (9·6) | 2·19 (0·66) | 2·92 (0·86) | 0·756 (0·09) |
| Total | 7721 | ||||||
| Replication studies | |||||||
| Study name | Total
Sample |
n (%) Male | Ever smokers,
n (%) |
Age, mean
(SD) |
FEV
1, litres.
mean (SD) |
FVC, litres.
mean (SD) |
FEV
1/FVC,
mean (SD) |
| UK Biobank | 98,657 | 45,166 (45·8%) | 56,404 (57·2%) | 56·7 (7·92) | 2·75 (0·80) | 3·67 (0·98) | 0·75 (0·07) |
| UK Household Longitudinal Study
(UKHLS) |
7443 | 3293 (44·2%) | 4509 (60·5%) | 53·10 (15·94) | 2·89 (0·90) | 3·83 (1·08) | 0·753 (0·09) |
| Netherlands Epidemiology of
Obesity study (NEO) |
5456 | 2672 (48·0%) | 3674 (66·0%) | 55·9 (5·9) | 3·26 (0·80) | 4·26 (1·02) | 0·77 (0·07) |
| Total | 111,556 |