Table 1.
Differentially expressed genes under conditions of wild-type PTEN induction and inhibition by LY294002
| Gene name | Accession no. | WT | LY | Description |
|---|---|---|---|---|
| Down-regulated by treatment | ||||
| Stathmin | AA873060 | −4.8 | −3.5 | Phosphoprotein. Cell proliferation and differentiation |
| Transforming growth factor β-1 | R36467 | −3.1 | −3.9 | Cell proliferation and differentiation |
| ADP-ribosylation factor-4 | T71316 | −4.0 | −4.0 | GTP binding protein, activator of phospholipase |
| ADP-ribosylation factor-like 1 | N51280 | −2.8 | −5.0 | GTP binding protein |
| HMG-CoA synthase | X83618 | −3.5 | −4.7 | Cholesterol synthesis |
| HMG-CoA reductase | AI038284 | −2.5 | −2.7 | Cholesterol synthesis |
| Squalene synthase | AA018779 | −2.6 | −4.0 | Cholesterol synthesis |
| Human homolog of yeast IPP isomerase | H08899 | −2.3 | −3.1 | Cholesterol synthesis |
| Homo sapiens mRNA for epiregulin | N31585 | −2.7 | −3.0 | Epidermal growth factor; tumor growth-inhibitory factor |
| Interferon-related developmental regulator 1 | AA676598 | −3.0 | −2.8 | Muscle differentiation and signal transduction |
| Cytochrome C | R52654 | −2.5 | −3.3 | Mediates the electron transfer |
| H. sapiens mRNA for TFG protein | R60846 | −2.4 | −2.3 | Transmembrane receptor tyrosine kinase protooncogene |
| ER lumen protein retaining receptor 2 | AA626867 | −2.5 | −3.7 | Sorting of proteins |
| Adrenergic, beta-2, receptor | H90431 | −2.4 | −3.2 | Transmembrane G protein-coupled receptor |
| Homo sapiens insulin induced protein | H59620 | −2.5 | −3.4 | Growth response |
| Glycyl-tRNA synthetase | AA629909 | −2.6 | −5.0 | Protein translation |
| Alanyl-tRNA synthetase | AA156571 | −3.2 | −5.7 | Protein translation |
| Up-regulated by treatment | ||||
| Cartilage glycoprotein-39 precursor | AA434115 | 3.5 | 3.2 | Deposition and remodeling of cartilage matrix |
| Human sigma receptor mRNA, comp | W47484 | 3.8 | 3.1 | Interaction with antipsychotic drugs; involved in psychiatric disorders |
| ESTs, highly similar to J KAPPA | R19314 | 2.8 | 3.2 | Recombination signal binding protein |
| Fibronectin 1 | N26285 | 4.2 | 2.4 | Cell adhesion, morphology and surface architecture |
| Lactate dehydrogenase A | AA48961 | 3.2 | 2.6 | Converts L-lactate to pyruvate during anaerobic glycolysis |
Genes that consistently show similar patterns of expression on PTEN induction or LY294002 treatment and not on induction of mutant PTEN (G129R) are tabulated. Values in the WT (induction of wild-type PTEN) and LY (treatment with LY294002) columns denote fold changes in expression. A negative value is assigned for repression and a positive value is assigned for induction. Accession nos. are from GenBank. Descriptions of genes are from National Center for Biotechnology Information databases.