Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
BTK is engaged downstream of the constitutively activated B cell receptor (BCR) in CLL. This leads to activation of phosphatidylinositol-3-kinase delta (PI3K?) and PLC?2 with subsequent hydrolysis of phosphatidylinositol-3-phosphate (PIP3) into diacylglycerol (DAG) and inositol-3-phosphate (IP3). Events downstream of activated BTK and PLC?2 include, but are not limited to, intracellular Ca2+ release as well as NF-?B and NFAT pathway activation.
