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. Author manuscript; available in PMC: 2018 Aug 8.
Published in final edited form as: Cell Rep. 2017 Nov 28;21(9):2458–2470. doi: 10.1016/j.celrep.2017.11.003

Figure 3. Basal Epigenetically Deregulated Pathways.

Figure 3

(A) Basal pathway enrichment of: overexpressed genes (mRNA), overexpressed and differentially methylated genes (Methylated), overexpressed genes that are targets of underexpressed microRNA (miRNA regulated), genes overexpressed in the stroma of basal tumors (Stroma), overexpressed genes in the basal tumors of the Moffitt et al. (2015) dataset (Moffitt et al.), the ICGC dataset (ICGC), and the TCGA dataset (TCGA), and genes overexpressed in basal tumors compared to normal pancreatic samples (Versus normal). Pathway definition originates from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database unless specified otherwise.

(B) Schematic illustration of the tumor and stromal deregulation of the WNT signaling pathway. Ellipses represent genes and hexagons miRNA found to be overexpressed (orange) or underexpressed (gray and crossed) in basal PDX tumors. Yellow circles indicate methylation-associated deregulation of expression. Rectangles represent genes overexpressed in basal PDX stroma. Blue-red heatmaps represent expression values of genes and miRNA. Blue-yellow heatmaps represent methylations values of CpG associated with genes. The CpGI annotation indicates that represented CpG methylation level originates from a CpG island. All heatmaps are shown with the same samples in the same order.