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. Author manuscript; available in PMC: 2018 Aug 8.
Published in final edited form as: Cell Rep. 2017 Nov 28;21(9):2458–2470. doi: 10.1016/j.celrep.2017.11.003

Figure 5. Classical Deregulated Tumor-Stroma Signaling Cross-Talk.

Figure 5

Schematic illustration of the overexpressed transporters and stromal pathways in classical tumors. Ellipses represent genes overexpressed (blue) in classical PDX tumors. Yellow circles indicate methylation-associated deregulation of expression. Rectangles represent genes overexpressed in classical PDX stroma. Boxplots show the levels of cholesteryl ester in basal and classical samples. Blue-red heatmaps represent expression values of genes and miRNA. Blue-yellow heatmaps represent methylations values of CpG associated with genes. Arrows indicate the hypothetical flow of cholesterol. All heatmaps are shown with the same samples in the same order.