Table 1. Repeat instability in Gc-r clones originated from cell lines containing CGG153-HyTK cassettes in the RL5 locus.
N of Trials | CGG153-HyTK clone | Cassette orientation | Total number of Gc-r clones | Number and percentile of Gc-r clones with repeat instability | Repeat length changes in unstable clones |
---|---|---|---|---|---|
2 | c2-29-1 | A | 58 | 31 (53%)* | 9 expansions (15%) 22 contractions (38%) |
2 | c2-29-2 | A | 57 | 43 (75%) | 15 expansions (26%) 28 contractions (49%) |
1 | c3-1 | A | 113 | 89 (80%) | 68 expansions (60%) 21 contractions (20%) |
1 | c2-38 | B | 15 | 9 (60%) | 3 expansions (20%) 6 contractions (40%) |
Total: | 243 | 172 (71%) |
95 expansions (39%) 77 contractions (32%) |