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Binding lifetimes of Aβ40 and IAPP as a function of alignment. In both cases the lifetime of the in-register state is two orders of magnitude greater than any other state. This separation of timescales allows for the growth of highly ordered fibrils. (inset) Binding energy EI as a function of alignment. The in-register state is a deep well at R = 0. The high energy of the R = ±1 states prevents the incorporation of these “near misses” in the fibril.
