Figure 9.

Comparison of the fibril growth rate and average registry computed by Eq. (28) and Eq. (29) (lines) and Gillespie simulation (dots). (a) Growth rate (molecules per second) as a function of the diffusion-limited binding rate. The theory, while quantitatively inaccurate, correctly predicts changes in the ranking of sequences as a function of concentration. (inset) The low concentration regime shows a sharp increase in the growth rate at the solubility concentration. (b) The theory also does a good job of predicting the relative order of average registries, even at low concentration. The HS_F has the most ordered fibrils at low concentration (small r_on), but becomes less ordered than the other sequences at high concentration when large registry mismatches become more common. These large mismatches promote binding events between H residues at opposite ends of the triblock. Error bars show the standard deviation from three simulations. ε₀ = 0.5, δ = 0.3