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. Author manuscript; available in PMC: 2018 Aug 8.
Published in final edited form as: J Neurotrauma. 2014 Nov 4;32(23):1893–1901. doi: 10.1089/neu.2014.3353

Table 5.

Causes of Death, and Standardized Mortality Ratios (SMRs) for Selected Causes

Organ system (ICD-9/ICD-10 codes) Observed deaths Percent Expected deaths SMRa 95% CI
Circulatory (390–459/I00–I99): 340.8 26% 239.8 1.42 1.27–1.57
Ischemic heart disease (410–414) 126.6 9.6%
Other heart disease (420–429) 81.2 6.1%
Cerebrovascular disease (430–439) 69.0 5.2%
Hypertensive disease (401–405) 29.8 2.2%
Arterial disease (440–449) 20.1 1.5%
Pulmonary circulation disease (415–417) 12.9 1.0%
Venous disease (451–459) 1.2 < 1%
Respiratory (460–519/J00–J98): 176.6 13% 67.5 2.62 2.23–3.00
Pneumonia (480–486/J12–J18) 80.0 6% 19.3 4.15 3.24–5.06
Chronic obstructive pulmonary disease (COPD) and allied conditions (490–496) 38.3 3%
Aspiration pneumonia (507/J69) 36.6 3% 5.7 6.40 4.33–8.48
Other respiratory disease 21.7 2%
Neoplasm (140–239): 116.3 9%
Other/unspecified site (190–199) 22.6 1.7%
Respiratory (160–169) 21.0 1.6%
Genitourinary (179–189) 20.1 1.5%
Uncertain behavior/unspecified nature (235–239) 19.0 1.4%
Digestive organs (150–159) 16.3 1.2%
Lymphatic/hematopoietic (200–208) 12.7 1.0%
Bone, breast (170–176) 3.9 < 1%
Neuroendocrine (209) 0.6 < 1%
External causes of injury and poisoning (E800–E999/V01–Y89): 92.8 7% 23.7 3.91 3.12–4.71
Fall (E880–E888/W00/W19) 30.7 2% 5.7 5.35 3.46–7.24
Accidental poisonings (E850–E869/X40–X49) 20.7 2% 1.9 10.68 6.08–15.28
Vehicular (E800–E848/V01–V99, Y85) 17.6 1% 5.1 3.44 1.83–5.05
Suicide (E950–E959/X60–X84, U03) 10.1 < 1% 3.8 2.64 1.01–4.27
Homicide (E960–E969/X85–Y09, U01–U02, Y87.1) 7.1 < 1% 1.4 4.92 1.30–8.54
Other accidents (E916–E928) 2.0 < 1%
Injury of unknown intent (E980–E989) 1.9 < 1%
Submersion, suffocation (E910–E915) 0.8 < 1%
Adverse effect of treatment (E934) 0.7 < 1%
Medical complication (E879) 1.3 < 1%
Infectious disease (001–139): 85.2 6%
Sepsis (038/A40–A41) 76.3 6% 8.1 9.37 7.26–11.47
Other infectious disease 8.9 < 1%
Nervous system (320–389/G00–G98): 63.8 5% 35.9 1.78 1.34–2.21
Hereditary/degenerative CNS disease (330–337) 56.5 4%
Other nervous system disease 7.3 < 1%
Mental disorders (290–319/F00–F99) 47.4 4% 21.8 2.17 1.55–2.79
Diseases of the genitourinary system (580–629) 35.9 3%
Diseases of the digestive system (520–579/K00–K92) 27.4 2% 18.2 1.51 0.94–2.07
Other signs, symptoms, ill–defined conditions (780–799, not 780.3) 24.4 2%
Diseases of the endocrine, immune, systems (240–279) 21.2 2%
Seizure (780.3/G40–G41, R56.8) 13.3 1% 0.3 50.00 23.15–76.84
Congenital anomalies (747) 10.4 < 1%
Diseases of blood (280–289) 2.7 < 1%
Diseases of the skin, subcutaneous, connective tissue (680–739) 0.8 < 1%
Unknown cause 266.5 20%
Total deaths 1325.4
a

Bolded SMRs are statistically significant; that is, the mortality of individuals with traumatic brain injury (TBI) is different from that of the general population.

ICD, International Classification of Diseases.