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. Author manuscript; available in PMC: 2018 Aug 8.
Published in final edited form as: Cell Rep. 2018 Jun 5;23(10):3021–3030. doi: 10.1016/j.celrep.2018.05.010

Figure 2. MSRN Protein Dysregulation Promotes Macrophage Foam Cell Formation.

Figure 2

(A and B) Peritoneal macrophage mRNA levels for several genes involved in cholesterol metabolism in WT C57BL/6 mice fed a LFD or a HFD (“obesity/IR only” model, A) or in Ldlr−/− mice fed chow, a WTD, or a HCLF diet (“HC ± obesity/IR” models, B).

(C) Peritoneal macrophage media protein levels for APOE and C3.

(D) Peritoneal macrophages were isolated from 8-week-old WT, Apoe−/−, or C3−/− C57BL/6 mice fed a LFD. Macrophages were treated were with and without 2% serum from WTD-fed Ldlr−/− mice, and cholesterol levels were quantified.

Results are mean ± SEM.

*p < 0.05 (t test). n = 5 mice/group.