Table 2. Distribution of genotypes and alleles in study groups.
| Groups (n) | LLI (218) | Controls (231) | OR(95% CI)** | p ** | p *** | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genes | Genotypes | Men | Women | Total | OR (95% CI)* | p * | Men | Women | Total | OR (95% CI)* | p * | |||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||||||
| 0.348 | 0.955 | 0.910 | ||||||||||||
| FOXO3 | GG | 6 (2.8) | 36 (16.5) | 42 (19.3) | (0.139-0.873) | 0.020 | 15 (6.5) | 33 (14.3) | 48 (20.8) | (0.482-1.894) | 0.896 | (0.573-1.445) | 0.689 | 0.907 |
| 1.425 | 0.869 | 1.073 | ||||||||||||
| GT | 38(17.4) | 80 (36.7) | 118(54.1) | (0.786-2.583) | 0.242 | 37 (16.0) | 84 (36.4) | 121(52.4) | (0.500-1.511) | 0.619 | (0.740-1.555) | 0.711 | ||
| 1.284 | 1.238 | 0.988 | ||||||||||||
| TT | 19 (8.7) | 39 (17.9) | 58 (26.6) | (0.671-2.458) | 0.449 | 22 (9.5) | 40 (17.3) | 62 (26.8) | (0.670 - 2.287) | 0.496 | (0.650-1.501) | 0.955 | ||
| SOD2 | ||||||||||||||
| 0.841 | 1.412 | 0.987 | ||||||||||||
| CC | 15 (6.9) | 42 (19.3) | 57 (26.1) | (0.426-1.659) | 0.617 | 23 (10.0) | 38 (16.5) | 61 (26.4) | (0.765-2.607) | 0.269 | (0.648-1.502) | 0.950 | 0.369 | |
| 1.070 | 0.821 | 1.238 | ||||||||||||
| CT | 36(16.5) | 86 (39.4) | 122(56.0) | (0.592-1.932) | 0.823 | 35 (15.1) | 82 (35.5) | 117(50.6) | (0.472-1.428) | 0.484 | (0.854-1.795) | 0.259 | ||
| 1.115 | 0.895 | 0.732 | ||||||||||||
| TT | 12 (5.5) | 27 (12.4) | 39 (17.9) | (0.525-2.370) | 0.776 | 16(6.9) | 37 (16.0) | 53 (22.9) | (0.460-1.740) | 0.743 | (0.461-1.162) | 0.185 | ||
| APOE | ||||||||||||||
| 1.291 | 0.996 | 1.088 | ||||||||||||
| ∊2∊3 | 10 (4.7) | 16 (7.5) | 26 (12.2) | (0.553-3.012) | 0.658 | 8 (3.8) | 20 (9.4) | 28 (13.2) | (0.412-2.401) | 1.000 | (0.615-1.927) | 0.884 | 0.973 | |
| 1.493 | 0.904 | 1.079 | ||||||||||||
| ∊3∊3 | 43(20.1) | 72 (33.8) | 115(53.9) | (0.837-2.662) | 0.191 | 33 (15.5) | 86 (40.4) | 119(55.9) | (0.498-1.643) | 0.762 | (0.736-1.580) | 0.770 | ||
| 0.492 | 2.542 | 0.796 | ||||||||||||
| ∊2∊4 | 1 (0.5) | 4 (1.9) | 5 (2.4) | (0.054-1.889) | 0.667 | 2 (0.9) | 2 (0.9) | 4 (1.8) | (0.350-18.468) | 0.324 | (0.211-3.006) | 1.000 | ||
| 0.547 | 1.105 | 0.885 | ||||||||||||
| ∊3∊4 | 14 (6.6) | 44 (20.7) | 58 (27.3) | (0.276-1.084) | 0.102 | 16 (7.5) | 37 (17.4) | 53 (24.9) | (0.560-2.182) | 0.861 | (0.574-1.365) | 0.659 | ||
| 1.000 | 0.702 | 1.000 | ||||||||||||
| ∊4∊4 | 3(1.4) | 6 (2.8) | 9 (4.2) | (0.243-4.121) | 1.000 | 2 (0.9) | 7 (3.3) | 9 (4.2) | (0.142-3.479) | 1.000 | (0.389-2.570) | 1.000 | ||
| SIRT1 | ||||||||||||||
| 2.508 | 2.137 | 2.140 | ||||||||||||
| CC | 2 (0.9) | 2 (0.9) | 4 (1.8) | (0.346-18.208) | 0.347 | 1 (0.4) | 1 (0.4) | 2 (0.8) | (0.132-34.643) | 0.584 | (0.388-11.804) | 0.438 | 0.660 | |
| 0.936 | 0.661 | 0.945 | ||||||||||||
| CT | 10 (4.6) | 26 (11.9) | 36 (16.5) | (0.422-2.076) | 0.871 | 10 (4.3) | 30 (13.0) | 40 (17.3) | (0.304-1.437) | 0.294 | (0.576-1.548) | 0.821 | ||
| 0.937 | 1.409 | 0.989 | ||||||||||||
| TT | 51(23.4) | 127(58.3) | 178(81.7) | (0.442-1.984) | 0.865 | 63 (27.3) | 126(54.5) | 189(81.8) | (0.665-2.987) | 0.370 | (0.613-1.596) | 0.964 | ||
| LLI | Controls | |||||||||||||
| Allele | n | % | n | % | p ** | OR (95%CI) | ||||||||
| 0.975 | ||||||||||||||
| FOXO3 | G | 202 | 46.3 | 217 | 47.0 | 0.848 | (0.750-1.267) | |||||||
| 1.026 | ||||||||||||||
| T | 234 | 53.7 | 245 | 53.0 | 0.472 | (0.789-1.334) | ||||||||
| SOD2 | C | 236 | 54.1 | 239 | 51.7 | 1.101 | ||||||||
| (0.847-1.431) | ||||||||||||||
| T | 200 | 45.9 | 223 | 48.3 | 0.908 | |||||||||
| (0.699-1.181) | ||||||||||||||
| APOE | ∊2 | 31 | 7.3 | 32 | 7.5 | 0.867 | 0.904 | |||||||
| (0.542-1.509) | ||||||||||||||
| ∊3 | 314 | 73.7 | 319 | 74.9 | 0.768 | |||||||||
| (0.576-1.024) | ||||||||||||||
| ∊4 | 81 | 19.0 | 75 | 17.6 | 1.018 | |||||||||
| (0.721-1.438) | ||||||||||||||
| SIRT1 | C | 44 | 10.1 | 44 | 9.5 | 0.775 | 1.066 | |||||||
| (0.687-1.656) | ||||||||||||||
| 0.938 | ||||||||||||||
| T | 392 | 89.9 | 418 | 90.5 | (0.604-1.456) | |||||||||
Abbreviations: n= number of individuals; LLI = Long-Lived Individuals; OR = Odds Ratio; CI = Confidence Interval;
*
Comparison between gender;
**
Comparison between CT and LLI;
***
p-values are uncorrected; For APOE, n= 213 (LLI) and n= 213 (Controls). FOXO3 (rs2802292:G>T. RefSeqNM_001455.3), SOD2 (rs4880:T>C. RefSeqNG_008729.1), SIRT1 (rs2273773:T>C. RefSeqNM_001142498.1) and APOE (rs429358:T>C. RefSeqNG_007084.2 and rs7412:C>T. RefSeqNG_007084.2).