Table 2. Allele and genotype distribution and frequencies of the ARNTL, CLOCK, CRY2 and PER2 polymorphisms.
| Gene | SNP | Minor allele | MAF* patients | MAF* controls | p-value | Genotype | Genotype frequency (%) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients with MI | Controls | p-value | X2 | q value | |||||||
| ARNTL1 | rs3789327 | C | 0.42 | 0.44 | 0.475 | CC | 33.5 | 34.0 | 0.301 | 2.34 | 0.443 |
| CT | 50.0 | 44.0 | |||||||||
| TT | 16.5 | 22.0 | |||||||||
| rs4757144 | A | 0.62 | 0.59 | 0.385 | AA | 39.5 | 36.0 | 0.694 | 0.73 | 0.867 | |
| AG | 45.5 | 46.5 | |||||||||
| GG | 15.0 | 17.5 | |||||||||
| rs12363415 | G | 0.15 | 0.17 | 0.501 | AA | 71.0 | 71.0 | 0.120 | 4.24 | 0.300 | |
| AG | 27.5 | 24.0 | |||||||||
| GG | 1.5 | 5.0 | |||||||||
| CLOCK | rs11932595 | G | 0.39 | 0.39 | 0.942 | AA | 36.5 | 35.0 | 0.878 | 0.26 | 0.878 |
| AG | 49.5 | 52.0 | |||||||||
| GG | 14.0 | 13.0 | |||||||||
| rs6811520 | T | 0.39 | 0.49 | 0.004 | CC | 37.5 | 31.0 | 0.005 | 10.55 | 0.050 | |
| CT | 47.0 | 40.0 | |||||||||
| TT | 15.5 | 29.0 | |||||||||
| rs13124436 | A | 0.33 | 0.28 | 0.143 | AA | 11.0 | 7.0 | 0.294 | 2.45 | 0.443 | |
| AG | 43.0 | 41.5 | |||||||||
| GG | 46.0 | 51.5 | |||||||||
| CRY2 | rs2292912 | G | 0.20 | 0.26 | 0.054 | CC | 62.0 | 55.5 | 0.056 | 5.78 | 0.197 |
| CG | 35.5 | 37.0 | |||||||||
| GG | 2.5 | 7.5 | |||||||||
| rs10838524 | A | 0.45 | 0.49 | 0.230 | AA | 19.0 | 26.3 | 0.212 | 3.11 | 0.424 | |
| AG | 52.5 | 46.5 | |||||||||
| GG | 28.5 | 27.2 | |||||||||
| PER2 | rs35333999 | T | 0.05 | 0.09 | 0.032 | CC | 91.5 | 84.0 | 0.059 | 5.64 | 0.197 |
| CT | 7.5 | 15.0 | |||||||||
| TT | 1.0 | 1.0 | |||||||||
| rs934945 | T | 0.17 | 0.19 | 0.644 | CC | 69.0 | 67.5 | 0.864 | 0.29 | 0.878 | |
| CT | 27.5 | 28.0 | |||||||||
| TT | 3.5 | 4.5 | |||||||||
*
MAF –minor allele frequency
Pearson Chi-square test
CLOCK SNP rs6811520 showed a departure from the Hardy-Weinberg equilibrium and was excluded
p-values shown in the table are corrected for the multiple comparisons.