Fig. 1.

a Schematic overview about the localization of desmin filaments (red) in cardiomyocytes. Of note, desmin filaments connect several protein-protein complexes (e.g., desmosomes) and cell organelles (mitochondria, nuclei) to the cytoskeletal network. b Transmission electron microscopy image of murine cardiac tissue. A typical desmosome connecting two cardiomyocytes is marked by the red box. c Schematic illustration of the cardiac desmosomes, which are connected to the desmin filaments. DSC2 = desmocollin-2, DSG2 = desmoglein-2, PKP2 = plakophilin-2, PG = plakoglobin, PM = plasma membrane, DSP = desmoplakin