Fig. 1.

Schematic two-dimensional illustration of a sarcomere bordered by Z-bands at either end. Thick, myosin-based filaments are in the center of the sarcomere (green), thin, actin-based filaments insert into the Z-band at either end of the sarcomere (red), and titin filaments (blue) run from the M-line in the middle of the sarcomere to the Z-band. Adapted from Granzier and Labeit (2007) with permission