Fig. 2.

Nesprin family members and isoforms reported in cardiomyocytes. Nesprin 1α2 contains an isoform-specific spectrin repeat (pink) followed by 6 other spectrin repeats (red) and a KASH domain (yellow). Nesprin 1 giant contains N-terminal tandem calponin homology (CH) domains (purple) that bind actin, spectrin repeats (orange), and a C-terminal KASH domain. Nesprin 2 giant contains tandem CH domains, abutted to spectrin repeats (orange) and a KASH domain. Nesprin 3α is comprised of an isoform-specific spectrin repeat (green) that binds plectin followed by 7 spectrin repeats (blue) and a KASH domain. Nesprin 3β is organized similarly to Nesprin 3α, but the isoform-specific spectrin repeat found in 3α