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Progressive growth plate widening on therapy. Tibial radiographs obtained prior to Cycle 1 (A), Cycle 9 (B), Cycle 16 (C), and Cycle 20 (D) show abnormal widening and irregularity of the distal femoral and proximal tibial physes. The physeal widening increases from the normal baseline seen prior to Cycle 1 (A) to become progressively more widened during the course of treatment.
