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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Biomaterials. 2018 Jun 18;178:293–301. doi: 10.1016/j.biomaterials.2018.06.025

Figure 2. Homing of biomimetic nanoclusters to injured carotid arteries.

Figure 2

Cy5-tagged nanoclusters were coated with platelet membranes, as described in Figure 1, and tail-vein injected (2.5 mg/kg animal weight) immediately after balloon angioplasty of the rat carotid artery. A. Balloon-Injured arteries and uninjured contralateral arteries were collected 5 days later for ex vivo imaging with an IVIS spectrum luminescence system (Ex/Em: 650/720 nm). More images from other 5 rats were presented in Figure S2. B. Quantification: Mean ± SEM, n=6 rats; *p<0.05. The intensity of basal level fluorescence from uninjured control (presented as 1) was used for normalization of the fluorescence in injured arteries.