Skip to main content
. Author manuscript; available in PMC: 2019 Jul 24.
Published in final edited form as: Lab Chip. 2018 Jul 24;18(15):2146–2155. doi: 10.1039/c8lc00035b

Figure 4.

Figure 4

Anti-thrombotic strategies for sensitized (cold-stored) whole blood. (A) Hypothermic blood storage results in platelet activation that generally potentiates clot formation. Stored blood forms clots rapidly even under low shear. The presence of tirofiban in blood storage effectively inhibited clot formation. n = 5 each for 48–72 hr and 48–72 hr +tiro. (B) Under high shear, tirofiban reduced clot formation but the amount of clot was still significant. The addition of GSH and NAC prior to blood processing further reduced clot formation. 48–72 hr, n = 6; 48–72 hr +tiro, n = 17; 48–72 hr +tiro +GSH, n = 9; 48–72 hr +tiro +NAC, n = 9. Data from fresh blood (0 hr data from Figure 3) are included as dotted lines as a baseline reference but is not used for statistical comparisons. Scale bars represent 100 μm.