(A) Scatterplot of NC ratio vs. normalized RG ratio of all analyzed sites stratified by pathology. An NC ratio threshold of 0.18 (horizontal dotted line) and normalized RG ratio threshold of 1.83 (vertical dotted line) correctly classified 91% of ModDys+ lesions. The multimodal imaging classifier combining both imaging methods (diagonal solid line) was also chosen to correctly classify 91% of ModDys+ lesions. (B) Scatterplot of NC ratio vs. normalized RG ratio of benign lesions (excluding mild dysplasia), stratified by inflammation status. Thresholds are identical to (A). (C) Percentage of sites correctly classified by AFI, HRME, and AFI+HRME using the thresholds in (A). (D) PPV and NPV of AFI, HRME, and AFI+HRME using the thresholds in (A) for the 56 lesions.