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. 2018 Jul 10;8(7):e021544. doi: 10.1136/bmjopen-2018-021544

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Percentage of syphilis episodes divided by symptom at presentation based on initial rapid plasma reagin (RPR) titre. Individuals who had symptoms compared with those that did not were more likely to have a higher initial RPR (p=0.0339). The most common symptoms were rash and ulcer/lesion with influenza-like illness, condylomata and lymphadenopathy being relatively rare. Those with neurological symptoms had a significant elevation of their initial RPR titres compared with all other symptoms (p=<0.001) and there were no cases of neurosyphilis with RPR titres less then 1:32 dilutions.