Fig 1. Dissection of the CD8 compartment of three T1D patients.

a) Overview HSNE of CD8 compartment, clustering was based on marker expression of 33 markers after hyperbolic Arcsin5 transformation. b) Density map including cluster number. A sigma value of 7 resulted in 42 clusters. c) Distribution of clusters per patient. d) Heat map view including variation in marker expression within a cluster (box fill–smaller box depicts higher variation).