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| Normalization method | Description of normalization | Distribution | Statistical test | Software packages |
|---|---|---|---|---|
| UQ-pgQ2 | Per sample scaled by upper quantile and per gene by medium across samples | NB | Wald test | DESeq2 (v1.6.3) |
| DESeq | Per sample scaled by medium of ratio | NB | Wald test | DESeq2 (v1.6.3) |
| TMM | Per sample by Trimmed Mean M values | NB | Exact test | edgeR (v3.8.6) |
NB: a negative binomial distribution.
