FIGURE 1.

Correlation between amino acid sequence-based human leukocyte antigen mismatch scoring methods; HLAMatchmaker eplet load vs. number of amino acid mismatches or sequence-based electrostatic mismatch score. This figure depicts analyses of the immunogenic potential of human leukocyte antigen class II mismatches in a large cohort of kidney transplant recipients using HLAMatchmaker and the Cambridge human leukocyte antigen immunogenicity algorithm. The strong correlation between number of eplet mismatches (eplet load), amino acid mismatches and sequence-based electrostatic mismatch score for human leukocyte antigen mismatches within the human leukocyte antigen-DRβ₁, human leukocyte antigen-DRβ_3/4/5, human leukocyte antigen-DQ_α1β1 loci is evident. Reproduced with permission [24^▪].