TABLE 1.

Weight change over the 10 days of the study

Treatment group	Weight change g	p-value versus air	p-value versus smoke
No pretreatment
Air	26±9	1	<0.001
Air+simvastatin	23±7	1	<0.001
Smoke	−23±7	<0.001	1
Smoke+simvastatin	−33±11	<0.001	0.476
1-week pretreatment
Air	12±10	1	<0.001
Air+simvastatin	−23±5	<0.001	<0.001
Smoke	−28±7	<0.001	1
Smoke+simvastatin	−53±8	<0.001	<0.001

Data are presented as mean±sd. Tobacco smoke or treatment with simvastatin for 1 week prior to smoke exposure and continued with exposure to tobacco smoke caused weight loss, while treatment with simvastatin only on the tobacco smoke exposure days had no effect. All groups were analysed by one-way ANOVA with Bonferroni corrections for multiple comparisons.