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. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Immunity. 2018 May 15;48(5):1006–1013.e6. doi: 10.1016/j.immuni.2018.04.020

Figure 4. Absence of osmotic tissue damage signaling does not block microbial detection.

Figure 4

(A) Left panel, Venn plot of significantly (padj<0.05), at least two times up- or down-regulated mRNAs at 60 min after PA ear infection in the absence (Iso + PA) or presence (Hypo + PA) of osmotic tissue damage signaling. Right panel, log2-fold regulation of intersection gene set (blue). Large font, known LPS-downstream effectors. See Table S1 for more detail. Results are derived from n=3 independent mRNAseq experiments (B) In situ hybridization for il1b mRNA. Left panel, representative images of different classes of staining patterns observed in indicated number of injection experiments (parentheses, right panel). Right panel, quantification of staining pattern frequency.